When working on my desktop, the work is farther away, so my #10 lens doesn't focus properly.
In this case, I usually use my #5 lens, which magnifies 2.5x and focuses at 8 inches (20 cm).
This works well since my desk is fairly high, and I can lower my chair if needed.
You might prefer a #4 or #3 lens for less magnification but a longer working distance.
Your height, especially sitting height, and desk height are important factors here.
More magnification means you have to be closer to the work, so finding the right balance takes time and adjustment.
Raising your work surface can help if you need more magnification, but for comfort, sometimes a less detailed view is better.